diff --git a/vllm/model_executor/layers/fused_moe/configs/E=128,N=384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8,block_shape=[128,128].json b/vllm/model_executor/layers/fused_moe/configs/E=128,N=384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8,block_shape=[128,128].json
new file mode 100644
index 00000000000..c275cecc159
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=128,N=384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8,block_shape=[128,128].json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}