diff --git a/internal/helm/registry/auth.go b/internal/helm/registry/auth.go
index a37e4c658..75667f1d5 100644
--- a/internal/helm/registry/auth.go
+++ b/internal/helm/registry/auth.go
@@ -1,3 +1,19 @@
+/*
+Copyright 2022 The Flux authors
+
+Licensed under the Apache License, Version 2.0 (the "License");
+you may not use this file except in compliance with the License.
+You may obtain a copy of the License at
+
+    http://www.apache.org/licenses/LICENSE-2.0
+
+Unless required by applicable law or agreed to in writing, software
+distributed under the License is distributed on an "AS IS" BASIS,
+WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+See the License for the specific language governing permissions and
+limitations under the License.
+*/
+
 package registry
 
 import (
@@ -6,6 +22,7 @@ import (
 	"net/url"
 
 	"github.com/docker/cli/cli/config"
+	"github.com/docker/cli/cli/config/credentials"
 	"helm.sh/helm/v3/pkg/registry"
 	corev1 "k8s.io/api/core/v1"
 )
@@ -30,6 +47,14 @@ func LoginOptionFromSecret(registryURL string, secret corev1.Secret) (registry.L
 		if err != nil {
 			return nil, fmt.Errorf("unable to get authentication data from Secret '%s': %w", secret.Name, err)
 		}
+
+		// Make sure that the obtained auth config is for the requested host.
+		// When the docker config does not contain the credentials for a host,
+		// the credential store returns an empty auth config.
+		// Refer: https://github.com/docker/cli/blob/v20.10.16/cli/config/credentials/file_store.go#L44
+		if credentials.ConvertToHostname(authConfig.ServerAddress) != parsedURL.Host {
+			return nil, fmt.Errorf("no auth config for '%s' in the docker-registry Secret '%s'", parsedURL.Host, secret.Name)
+		}
 		username = authConfig.Username
 		password = authConfig.Password
 	} else {
diff --git a/internal/helm/registry/auth_test.go b/internal/helm/registry/auth_test.go
new file mode 100644
index 000000000..921ecbf14
--- /dev/null
+++ b/internal/helm/registry/auth_test.go
@@ -0,0 +1,131 @@
+/*
+Copyright 2022 The Flux authors
+
+Licensed under the Apache License, Version 2.0 (the "License");
+you may not use this file except in compliance with the License.
+You may obtain a copy of the License at
+
+    http://www.apache.org/licenses/LICENSE-2.0
+
+Unless required by applicable law or agreed to in writing, software
+distributed under the License is distributed on an "AS IS" BASIS,
+WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+See the License for the specific language governing permissions and
+limitations under the License.
+*/
+
+package registry
+
+import (
+	"testing"
+
+	. "github.com/onsi/gomega"
+	corev1 "k8s.io/api/core/v1"
+)
+
+func TestLoginOptionFromSecret(t *testing.T) {
+	testURL := "oci://registry.example.com/foo/bar"
+	testUser := "flux"
+	testPassword := "somepassword"
+	testDockerconfigjson := `{"auths":{"registry.example.com":{"username":"flux","password":"somepassword","auth":"Zmx1eDpzb21lcGFzc3dvcmQ="}}}`
+	testDockerconfigjsonHTTPS := `{"auths":{"https://registry.example.com":{"username":"flux","password":"somepassword","auth":"Zmx1eDpzb21lcGFzc3dvcmQ="}}}`
+	dockerconfigjsonKey := ".dockerconfigjson"
+
+	tests := []struct {
+		name       string
+		url        string
+		secretType corev1.SecretType
+		secretData map[string][]byte
+		wantErr    bool
+	}{
+		{
+			name:       "generic secret",
+			url:        testURL,
+			secretType: corev1.SecretTypeOpaque,
+			secretData: map[string][]byte{
+				"username": []byte(testUser),
+				"password": []byte(testPassword),
+			},
+		},
+		{
+			name:       "generic secret without username",
+			url:        testURL,
+			secretType: corev1.SecretTypeOpaque,
+			secretData: map[string][]byte{
+				"password": []byte(testPassword),
+			},
+			wantErr: true,
+		},
+		{
+			name:       "generic secret without password",
+			url:        testURL,
+			secretType: corev1.SecretTypeOpaque,
+			secretData: map[string][]byte{
+				"username": []byte(testUser),
+			},
+			wantErr: true,
+		},
+		{
+			name:       "generic secret without username and password",
+			url:        testURL,
+			secretType: corev1.SecretTypeOpaque,
+		},
+		{
+			name:       "docker-registry secret",
+			url:        testURL,
+			secretType: corev1.SecretTypeDockerConfigJson,
+			secretData: map[string][]byte{
+				dockerconfigjsonKey: []byte(testDockerconfigjson),
+			},
+		},
+		{
+			name:       "docker-registry secret host mismatch",
+			url:        "oci://registry.gitlab.com",
+			secretType: corev1.SecretTypeDockerConfigJson,
+			secretData: map[string][]byte{
+				dockerconfigjsonKey: []byte(testDockerconfigjson),
+			},
+			wantErr: true,
+		},
+		{
+			name:       "docker-registry secret invalid host",
+			url:        "oci://registry .gitlab.com",
+			secretType: corev1.SecretTypeDockerConfigJson,
+			secretData: map[string][]byte{
+				dockerconfigjsonKey: []byte(testDockerconfigjson),
+			},
+			wantErr: true,
+		},
+		{
+			name:       "docker-registry secret invalid docker config",
+			url:        testURL,
+			secretType: corev1.SecretTypeDockerConfigJson,
+			secretData: map[string][]byte{
+				dockerconfigjsonKey: []byte("foo"),
+			},
+			wantErr: true,
+		},
+		{
+			name:       "docker-registry secret with URL scheme",
+			url:        testURL,
+			secretType: corev1.SecretTypeDockerConfigJson,
+			secretData: map[string][]byte{
+				dockerconfigjsonKey: []byte(testDockerconfigjsonHTTPS),
+			},
+		},
+	}
+
+	for _, tt := range tests {
+		t.Run(tt.name, func(t *testing.T) {
+			g := NewWithT(t)
+
+			secret := corev1.Secret{}
+			secret.Name = "test-secret"
+			secret.Data = tt.secretData
+			secret.Type = tt.secretType
+
+			_, err := LoginOptionFromSecret(tt.url, secret)
+			g.Expect(err != nil).To(Equal(tt.wantErr))
+		})
+	}
+}