diff --git a/elastic_transport/_node/_http_httpx.py b/elastic_transport/_node/_http_httpx.py
index 04ceb60..03316a9 100644
--- a/elastic_transport/_node/_http_httpx.py
+++ b/elastic_transport/_node/_http_httpx.py
@@ -102,7 +102,7 @@ def __init__(self, config: NodeConfig):
                     ssl_context.load_cert_chain(config.client_cert)
 
         self.client = httpx.AsyncClient(
-            base_url=f"{config.scheme}://{config.host}:{config.port}",
+            base_url=f"{config.scheme}://{config.host}:{config.port}{config.path_prefix}",
             limits=httpx.Limits(max_connections=config.connections_per_node),
             verify=ssl_context or False,
             timeout=config.request_timeout,